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2014-03-27

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cc-by (c) Soto, Sara M. (Sara Maria), 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/121811

Importance of biofilms in urinary tract infections: new therapeutic approaches

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https://doi.org/10.1155/2014/543974

Abstract

Bacterial biofilms play an important role in urinary tract infections (UTIs), being responsible for persistence infections causing relapses and acute prostatitis. Bacterial forming biofilm are difficult to eradicate due to the antimicrobial resistant phenotype that this structure confers being combined therapy recommended for the treatment of biofilm-associated infections. However, the presence of persistent cells showing reduced metabolism that leads to higher levels of antimicrobial resistance makes the search for new therapeutic tools necessary. Here, a review of these new therapeutic approaches is provided including catheters coated with hydrogels or antibiotics, nanoparticles, iontophoresis, biofilm enzyme inhibitors, liposomes, bacterial interference, bacteriophages, quorum sensing inhibitors, low-energy surface acoustic waves, and antiadhesion agents. In conclusion, new antimicrobial drugs that inhibit bacterial virulence and biofilm formation are needed.

Subject

Infeccions del tracte urinari, Medicaments antibacterians, Biofilms, Resistència als medicaments, Terapèutica

Subject (English)

Urinary tract infections, Antibacterial agents, Biofilms, Drug resistance, Therapeutics

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Articles publicats en revistes (Fonaments Clínics)

Citation

SOTO GONZÁLEZ, Sara M. Importance of biofilms in urinary tract infections: new therapeutic approaches. Advances in Biology . 2014. Vol. 2014. ISSN 2356-6582. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/121811

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