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2019-04-14

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cc-by-nc (c) Rodriguez, Celestino et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/164851

Supplementation with high-content docosahexaenoic acid triglyceride in attention-deficit hyperactivity disorder: a randomized double-blind placebo-controlled trial.

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https://doi.org/10.2147/NDT.S206020

Abstract

Background: Attention-deficit hyperactivity disorder (ADHD) is a complex disorder in terms of etiology, clinical presentation, and treatment outcome. Pharmacological and psychological interventions are recommended as primary treatments in ADHD; however, other nonpharmacological intervention such as a dietary supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has emerged as an attractive option. Purpose: The objective of the present study was to assess whether dietary supplementation with highly concentrated ω-3 docosahexaenoic acid (DHA) triglyceride may improve symptoms in ADHD. Method: A 6-month prospective double-blind placebo-controlled randomized clinical trial was designed in 66 patients with ADHD, aged between 6 and 18 years. Participants in the experimental group received a combination of ω-3 fatty acids (DHA 1,000 mg, eicosapentaenoic acid 90 mg, and docosapentaenoic acid 150 mg). Instruments included d2-test, AULA Nesplora, EDAH scales, and abbreviated Conner's Rating Scale. Results: In the cognitive test, between-group differences were not found, but within-group differences were of a greater magnitude in the DHA group. Between-group differences in favor of the DHA arm were observed in behavioral measures, which were already detected after 3 months of treatment. Results were not changed when adjusted by ADHD medication. Conclusions: This study provides further evidence of the beneficial effect of supplementation with ω-3 DHA in the management of ADHD.

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Trastorns per dèficit d'atenció amb hiperactivitat en els adults, Suplements nutritius

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Attention deficit disorder with hyperactivity in adults, Dietary supplements

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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RODRIGUEZ, Celestino, et al. Supplementation with high-content docosahexaenoic acid triglyceride in attention-deficit hyperactivity disorder: a randomized double-blind placebo-controlled trial. Neuropsychiatric Disease and Treatment. 2019. Vol. 15, num. 1193-1209. ISSN 1176-6328. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/164851

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