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2024-01-15

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227363

Infective endocarditis after transcatheter versus surgical aortic valve replacement

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https://doi.org/10.1093/cid/ciad464

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Abstract Background Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, and outcomes of IE after SAVR versus TAVR. Methods Data were collected from the “Infectious Endocarditis after TAVR International” (enrollment from 2005 to 2020) and the “International Collaboration on Endocarditis” (enrollment from 2000 to 2012) registries. Only patients with an IE affecting the aortic valve prosthesis were included. A 1:1 paired matching approach was used to compare patients with TAVR and SAVR. Results A total of 1688 patients were included. Of them, 602 (35.7%) had a surgical bioprosthesis (SB), 666 (39.5%) a mechanical prosthesis, 70 (4.2%) a homograft, and 350 (20.7%) a transcatheter heart valve. In the SAVR versus TAVR matched population, the rate of new moderate or severe aortic regurgitation was higher in the SB group (43.4% vs 13.5%; P < .001), and fewer vegetations were diagnosed in the SB group (62.5% vs 82%; P < .001). Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P < .001) and Staphylococcus aureus was less common in this group (13.4% vs 22%; P = .033). Despite a higher rate of surgery in patients with SB (44.4% vs 27.3%; P < .001), 1-year mortality was similar (SB: 46.5%; TAVR: 44.8%; log-rank P = .697). Conclusions Clinical presentation, type of causative microorganism, and treatment differed between patients with an IE located on SB compared with TAVR. Despite these differences, both groups exhibited high and similar mortality at 1-year follow-up.

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Endocarditis, Pròtesis valvulars cardíaques, Cirurgia cardiovascular

Matèries (anglès)

Endocarditis, Heart valve prosthesis, Cardiovascular surgery

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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PANAGIDES, Vassili, CUERVO REQUENA, Guillermo, LLOPIS PÉREZ, Jaime, ABDEL-WAHAB, Mohamed, MANGNER, Norman, HABIB, Gilbert, REGUEIRO, Ander, MESTRES, Carlos a., TORNOS, Pilar, DURAND, Eric, SELTON SUTY, Christine, IHLEMANN, Nikolaj, BRUUN, Niels e, URENA, Marina, CECCHI, Enrico, THIELE, Holger, DURANTE MANGONI, E., PELLEGRINI, Costanza, ELTCHANINOFF, Helene, ATHAN, Eugene, SØNDERGAARD, Lars, LINKE, Axel, TATTEVIN, Pierre, VAL, David del, QUINTANA, Eduard, CHU, Vivian, RODÉS CABAU, Josep, MIRÓ MEDA, José m. (josé maría), TAVI Infective Endocarditis International Registry and ICE Investigators. Infective endocarditis after transcatheter versus surgical aortic valve replacement. _Clinical Infectious Diseases_. 2024. Vol. 78, núm. 1, pàgs. 179-187. [consulta: 1 de març de 2026]. ISSN: 1058-4838. [Disponible a: https://hdl.handle.net/2445/227363]

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