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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/113335
Golimumab as rescue therapy for refractory immune-mediated uveitis: a three-center experience
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Objective. To evaluate, in three Spanish tertiary referral centres, the short-term safety and efficacy of golimumab (GLM) for treatment of immune-mediated uveitis resistant to previous immunosuppressive therapy. Methods. Nonrandomized retrospective interventional case series. Thirteen patients with different types of uveitis that were resistant to treatment with at least 2 previous immunosuppressors were included in this study. All included patients were treated with GLM (50 mg every four weeks) during at least 6 months. Clinical evaluation and treatment-related side effects were assessed at least four times in all included patients. Results. Eight men and 5 women (22 affected eyes) with a median age of 30 years (range 20-38) and active immune-mediated uveitides were studied. GLM was used in combination with conventional immunosuppressors in 7 patients (53.8%). GLM therapy achieved complete control of inflammation in 12/13 patients (92.3%) after six months of treatment. There was a statistically significant improvement in mean BCVA (0.60 versus 0.68, P - 0.009) and mean 1 mm central retinal thickness (317 versus 261.2 mu, P -0.05) at the six-month endpoint when compared to basal values. No major systemic adverse effects associated with GLM therapy were observed. Conclusions. GLM is a new and promising therapeutic option for patients with severe and refractory uveitis.
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CORDERO COMA, Miguel, CALVO RÍO, Vanesa, ADÁN CIVERA, Alfredo, BLANCO, Ricardo, ÁLVAREZ CASTRO, Carolina, MESQUIDA, Marina, CALLEJA, Sara, GONZÁLEZ-GAY, Miguel a., RUÍZ DE MORALES, José g.. Golimumab as rescue therapy for refractory immune-mediated uveitis: a three-center experience. _Mediators of Inflammation_. 2014. Vol. 2014. [consulta: 24 de gener de 2026]. ISSN: 0962-9351. [Disponible a: https://hdl.handle.net/2445/113335]