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mira-martinez2017_2510.pdf (750.12 KB)

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2017-02-07

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/110938

Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections

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http://dx.doi.org/10.1093/infdis/jix053

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Background.: Many genes of the malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic level. These genes participate in fundamental host-parasite interactions and contribute to adaptive processes. However, little is known about their expression patterns during human infections. A peculiar case of clonally variant genes are the 2 nearly identical clag3 genes, clag3.1 and clag3.2, which mediate nutrient uptake and are linked to resistance to some toxic compounds. Methods.: We developed a procedure to characterize the expression of clag3 genes in naturally infected patients and in experimentally infected human volunteers. Results.: We provide the first description of clag3 expression during human infections, which revealed mutually exclusive expression and identified the gene predominantly expressed. Adaptation to culture conditions or selection with a toxic compound resulted in isolate-dependent changes in clag3 expression. We also found that clag3 expression patterns were reset during transmission stages. Conclusions.: Different environment conditions select for parasites with different clag3 expression patterns, implying functional differences between the proteins encoded. The epigenetic memory is likely erased before parasites start infection of a new human host. Altogether, our findings support the idea that clonally variant genes facilitate the adaptation of parasite populations to changing conditions through bet-hedging strategies.

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Malària, Plasmodium falciparum

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Malaria, Plasmodium falciparum

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Articles publicats en revistes (ISGlobal)

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MIRA MARTÍNEZ, Sofía, SCHUPPEN, Evi van, AMAMBUA-NGWA, Alfred, BOTTIEAU, Emmanuel, AFFARA, Muna, ESBROECK, Marjan van, VLIEGHE, Erika, GUETENS, Pieter, ROVIRA GRAELLS, Núria, GOMEZ-PEREZ, Gloria p., ALONSO, Pedro, D'ALESSANDRO, Umberto, ROSANAS URGELL, Anna, CORTÉS, Alfred. Expression of the Plasmodium falciparum Clonally Variant clag3
                Genes in Human Infections. _The Journal of Infectious Diseases_. 2017. Vol. 215, núm. 6, pàgs. 938-945. [consulta: 20 de gener de 2026]. ISSN: 0022-1899. [Disponible a: https://hdl.handle.net/2445/110938]

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