Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/168554
Fatty acid metabolism and the basis of brown adipose tissue function
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Obesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally white adipose tissue has captured the most attention. However in the last decade the presence and activity of heat-generating brown adipose tissue (BAT) in adult humans has been rediscovered. BAT decreases with age and in obese and diabetic patients. It has thus attracted strong scientific interest, and any strategy to increase its mass or activity might lead to new therapeutic approaches to obesity and associated metabolic diseases. In this review we highlight the mechanisms of fatty acid uptake, trafficking and oxidation in brown fat thermogenesis. We focus on BAT's morphological and functional characteristics and fatty acid synthesis, storage, oxidation and use as a source of energy.
Subject
Subject (English)
Citation
Citation
CALDERÓN DOMÍNGUEZ, María, et al. Fatty acid metabolism and the basis of brown adipose tissue function. Adipocyte. 2016. Vol. 5, num. 2, pags. 98-118. ISSN 2162-3945. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/168554