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2017-11-16

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cc-by (c) López-Vicario, Cristina et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126199

Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals

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https://doi.org/10.1038/s41598-017-15951-z

Resum

Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.

Matèries

Teixit adipós, Obesitat mòrbida, Inflamació, Comorbiditat, Polimorfisme genètic

Matèries (anglès)

Adipose tissues, Morbid obesity, Inflammation, Comorbidity, Genetic polymorphisms

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

LÓPEZ VICARIO, Cristina, RIUS, Bibiana, ALCARAZ-QUILES, José, GONZÁLEZ PÉRIZ, Ana, MARTÍNEZ PUCHOL, Ana isabel, CASULLERAS, Mireia, DURAN GÜELL, Marta, IBARZABAL, Ainitze, CORCELLES CODINA, Ricard, LAGUNA FERNÁNDEZ, Andrés, BÄCK, Magnus, TITOS RODRÍGUEZ, Esther, CLÀRIA I ENRICH, Joan. Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals. _Scientific Reports_. 2017. Vol. 7, núm. 15724. [consulta: 14 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/126199]

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