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514772.pdf (4.13 MB)

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2001

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cc-by-nc-nd (c) Universidad de Murcia, 2001
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104404

Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1

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Resum

Gastric cancer is one of the most frequent malignancies and its treatment is far from satisfactory. The challenge to oncologists is the characterization of novel chemical entities with greater effectiveness. Prodigiosin is a red pigment produced by various bacteria including Serratia marcescens. Here we characterize the apoptotic action of prodigiosin in human gastric carcinoma cell line (HGT-1). Cells were assayed by the MTT assay, fragmentation pattern of DNA, Hoechst 33342 staining and study of actin microfilament architecture. Treatment of these cells with prodigiosin showed a constant decrease in viability by apoptosis. Morphological analysis of prodigiosin-treated cells demonstrated that prodigiosin induces cell shrinkage, chromatin condensation, reorganization of actin microfilament architecture, and detachment of cells from the cell culture substrate. Altogether these results suggest that prodigiosin induces apoptosis in HGT-1 human gastric cancer cells and raises the possibility of its use as a new chemotherapeutic drug.

Matèries

Serratia marcescens, Apoptosi, Malalties de l'estómac, Oncologia, Cèl·lules canceroses, Malalties de l'esòfag, Proliferació cel·lular, Malalties del tracte gastrointestinal

Matèries (anglès)

Serratia marcescens, Apoptosis, Stomach diseases, Oncology, Cancer cells, Esophagus diseases, Cell proliferation, Gastrointestinal system diseases

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

DÍAZ RUIZ, Carmen, MONTANER RAMONEDA, Beatriz and PÉREZ TOMÁS, Ricardo E. Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1. Histology and Histopathology. 2001. Vol. 16, num. 2, pags. 415-421. ISSN 0213-3911. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/104404

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