Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184823
Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.
Matèries (anglès)
Citació
Col·leccions
Citació
CLÀRIA I ENRICH, Joan. Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.. _Advances in Laboratory Medicine/Avances en Medicina de Laboratorio_. 2021. Vol. 2, núm. 4, pàgs. 516-527. [consulta: 21 de gener de 2026]. ISSN: 2628-491X. [Disponible a: https://hdl.handle.net/2445/184823]