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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219221
Dietary Supplementation with Spray-dried Animal Plasma Improves Vaccine Protection in Aged Mice
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Background: Senescence is characterized by an aggravated inflammatory state that reduces vaccine responsiveness. Dietary supplementation with spray-dried porcine plasma (SDP) exerts anti-inflammatory effects in different mucosal areas. We aimed to determine if the anti-inflammatory properties of SDP improve the efficiency of immunization in senescent animals.
Methods: Experiments were performed in 2-month-old and 6-month-old male SAMP8 mice fed control or SDP (8%) feeds for 4 months. The mice received nasal doses of 2.5 μg of Staphylococcus aureus enterotoxin B (SEB) or vehicle every 15 days (i.e., 3 times). Fifteen days after the last dose, a lethal shock was induced by intraperitoneal administration of SEB and LPS.
Results: Immunization increased anti-SEB IgA in intestinal and bronchoalveolar fluid (p < 0.05). After the lethal shock, all immunized aged mice that were supplemented with SDP survived, in contrast to only 66% of those fed the control feed (p < 0.05). Moreover, after the lethal challenge, aged mice showed higher expression levels of pro-inflammatory cytokines (Il-6, Tnf-α, Ifn-γ, and Il-1β) in jejunal and (Tnf-α, and Il-1β) in lung tissues (p < 0.05), which were reduced by SDP supplementation (p < 0.05). Furthermore, in senescent mice, SDP supplementation augmented Il-4 and Il-10 expression in both tissues (p < 0.05).
Conclusion: SDP reduces the mucosal inflammation associated with aging, improving vaccine protection in senescent mice.
Keywords: dietary supplementation; immune protection; immunization; senescence; spray-dried porcine plasma.
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MIRÓ MARTÍ, Ma. lluïsa, ROSELL CARDONA, Cristina, AMAT, Concepció, POLO POZO, Francisco javier, MORETÓ, Miquel, PÉREZ BOSQUE, Anna. Dietary Supplementation with Spray-dried Animal Plasma Improves Vaccine Protection in Aged Mice. _Frontiers In Nutrition_. 2023. Vol. 10. [consulta: 20 de gener de 2026]. ISSN: 2296-861X. [Disponible a: https://hdl.handle.net/2445/219221]