Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/48611
On the role of G protein-coupled receptors oligomerization
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community. Indeed, GPCR oligomers may enhance the diversity and performance by which extracellular signals are transferred to the G proteins in the process of receptor transduction, although the mechanism that underlies this phenomenon still remains unsolved. Recently, it has been proposed that a trans-conformational switching model could be the mechanism allowing direct inhibition/activation of receptor activation/inhibition, respectively. Thus, heterotropic receptor-receptor allosteric regulations are behind the GPCR oligomeric function. In this paper we want to revise how GPCR oligomerization impinges on several important receptor functions like biosynthesis, plasma membrane diffusion or velocity, pharmacology and signaling. In particular, the rationale of receptor oligomerization might lie in the need of sensing complex whole cell extracellular signals and translating them into a simple computational model.
Subject
Subject (English)
Citation
Citation
GÓMER SOLER, Maricel, et al. On the role of G protein-coupled receptors oligomerization. The Open Biology Journal. 2011. Vol. 4, num. 1, pags. 47-53. ISSN 1874-1967. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/48611