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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/151706
Synthesis and Antiproliferative activity of novel A-ring cleaved glycyrrhetinic acid derivatives
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A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines. Compound 17 was the most active compound, with an IC50 of 6.1 µM on Jurkat cells, which is 17-fold more potent than that of glycyrrhetinic acid, and was up to 10 times more selective toward that cancer cell line. Further biological investigation in Jurkat cells showed that the antiproliferative activity of compound 17 was due to cell cycle arrest at the S phase and induction of apoptosis.
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ALHO, Daniela P.S., et al. Synthesis and Antiproliferative activity of novel A-ring cleaved glycyrrhetinic acid derivatives. Molecules. 2019. Vol. 24, num. 16, pags. E2938. ISSN 1420-3049. [consulted: 17 of October of 2026]. Available at: https://hdl.handle.net/2445/151706