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2020-12-09

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cc-by (c) Grau-Bové, Carme et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172736

Modulation of food intake by differential TAS2R stimulation in rat

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Recurs relacionat

https://doi.org/10.3390/nu12123784

Resum

Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats.

Matèries

Receptors cel·lulars, Consum d'aliments, Sentits

Matèries (anglès)

Cell receptors, Food consumption, Senses

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

GRAU-BOVÉ, Carme, et al. Modulation of food intake by differential TAS2R stimulation in rat. Nutrients. 2020. Vol. 12, num. 12, pags. 3784. ISSN 2072-6643. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/172736

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