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2018-08-08

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cc-by-nc-nd (c) Elsevier B.V., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127666

Chasing the elusive hold-up time from an LFER approach

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https://doi.org/10.1016/j.chroma.2018.08.017

Abstract

A homologous series approach derived from the Abraham's solvation model was developed for the determination of hold-up times. Firstly, it was tested from reversed-phase liquid chromatography data obtained in the literature involving several series of homologues, followed by its application in a polymeric zwitterionic HILIC column using two different homologous series (n-alkyl benzenes and n-alkyl phenones). Acetonitrile and methanol were selected as organic modifiers in a composition range between 80% and 100% in volume. Results obtained for both series were consistent, and hold-up times were found to be strongly dependent on the water content and the organic modifier nature of the mobile phase.

Subject

Cromatografia de líquids, Nitrosamines, Termodinàmica

Subject (English)

Liquid chromatography, Nitrosoamines, Thermodynamics

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citation

SUBIRATS I VILA, Xavier, JUSTICIA, Althea and ROSÉS PASCUAL, Martí. Chasing the elusive hold-up time from an LFER approach. Journal of Chromatography A. 2018. Vol. 1571, num. 176-184. ISSN 0021-9673. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/127666

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