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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127666
Chasing the elusive hold-up time from an LFER approach
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A homologous series approach derived from the Abraham's solvation model was developed for the determination of hold-up times. Firstly, it was tested from reversed-phase liquid chromatography data obtained in the literature involving several series of homologues, followed by its application in a polymeric zwitterionic HILIC column using two different homologous series (n-alkyl benzenes and n-alkyl phenones). Acetonitrile and methanol were selected as organic modifiers in a composition range between 80% and 100% in volume. Results obtained for both series were consistent, and hold-up times were found to be strongly dependent on the water content and the organic modifier nature of the mobile phase.
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SUBIRATS I VILA, Xavier, JUSTICIA, Althea and ROSÉS PASCUAL, Martí. Chasing the elusive hold-up time from an LFER approach. Journal of Chromatography A. 2018. Vol. 1571, num. 176-184. ISSN 0021-9673. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/127666