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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/200286
Targeting lymphoid-derived IL-17 signaling to delay skin aging
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Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored by proinflammatory microenvironments that drive pleotropic changes. The nature of these age-associated inflammatory cues, or how they affect tissue aging, is unknown. Based on single-cell RNA sequencing of the dermal compartment of mouse skin, we show a skew towards an IL-17-expressing phenotype of T helper cells, γδ T cells and innate lymphoid cells in aged skin. Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age-related traits. Mechanistically, aberrant IL-17 signals through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state. Our results indicate that aged skin shows signs of chronic inflammation and that increased IL-17 signaling could be targeted to prevent age-associated skin ailments.© 2023. The Author(s).
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SOLÁ CASTRILLO, Paloma, MEREU, Elisabetta, BONJOCH, Júlia, CASADO PELÁEZ, Marta, PRATS, Neus, AGUILERA, Mònica, REINA, Oscar, BLANCO, Enrique, ESTELLER, Manel, CROCE, Luciano di, HEYN, Holger, SOLANAS FUSTER, Guiomar, BENITAH, Salvador a.. Targeting lymphoid-derived IL-17 signaling to delay skin aging. _Nature Aging_. 2023. Vol. 3, núm. 6, pàgs. 688-704. [consulta: 10 de gener de 2026]. ISSN: 2662-8465. [Disponible a: https://hdl.handle.net/2445/200286]