Document type
ArticleVersion
Submitted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/118858
Ceramides and mitochondrial fatty acid oxidation in obesity
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
: Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and low-grade inflammation in the circulation, among other factors. It creates the perfect scenario for the production of ceramide, the building block of the sphingolipid family of lipids, which is involved in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, obesity causes a decrease in fatty acid oxidation (FAO), which contributes to lipid accumulation within the cells, conferringmore susceptibility to cell dysfunction. C16:0 ceramide, a specific ceramide species, has been identified recently as the principal mediator of obesity-derived insulin resistance, impaired fatty acid oxidation, and hepatic steatosis. In this review, we have sought to cover the importance of the ceramide species and their metabolism, the main ceramide signaling pathways in obesity, and the link between C16:0 ceramide, FAO, and obesity.¿Fucho, R., Casals, N., Serra, D., Herrero, L. Ceramides and mitochondrial fatty acid oxidation in obesity. FASEB J. 31, 000-000 (2017). www.fasebj.org
Related resource
Subject (English)
Citation
Citation
FUCHO SALVADOR, Raquel, et al. Ceramides and mitochondrial fatty acid oxidation in obesity. The FASEB Journal . 2016. Vol. 31, num. 1-10. ISSN 0892-6638. [consulted: 12 of October of 2026]. Available at: https://hdl.handle.net/2445/118858