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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/67004
Neurobiology of drug addiction: animal behavioral paradigms, and MDPV as an example of addictive cathinones
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[eng] Synthetic cathinones, colloquially referred to as “bath salts” are derivatives of the psychoactive alkaloid found in Catha edulis, cathinone. Mephedrone and 2,3-methylenedioxypyrovalerone or MDPV are examples of these amphetamine-like psychostimulants. Its use has increased worldwide in past years, becoming a health and a legal problem.
MDPV and mephedrone as drugs of abuse can induce drug addiction; a chronically relapsing disorder which is defined by a compulsion to take the drug and a loss of control in limiting intake. Here, within the context of neurobiology of drug addiction, mechanisms involved in the development of addiction, including molecular and cellular changes induced in the rewarding circuit after repeated exposure to drugs of abuse are described.
Animal behavioral paradigms are critical to study the reinforcing effects of drugs of abuse. In the present study, conditioned place preference (CPP) paradigm was used to study the reinforcing properties of MDPV in rats. Different doses of MDPV (1, 3, 5 mg/kg s.c.) showed a significant place preference compared with saline controls.
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Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2015. Tutora: Elena Escubedo Rafa.
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ROURA TURET, Judit. Neurobiology of drug addiction: animal behavioral paradigms, and MDPV as an example of addictive cathinones. [consulta: 7 de desembre de 2025]. [Disponible a: https://hdl.handle.net/2445/67004]