Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/164430
Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Chitosan is increasingly used for safe nucleic acid delivery in gene therapy studies, due to well-known properties such as bioadhesion, low toxicity, biodegradability and biocompatibility. Furthermore, chitosan derivatization can be easily performed to improve the solubility and stability of chitosan-nucleic acid polyplexes, and enhance e cient target cell drug delivery, cell uptake, intracellular endosomal escape, unpacking and nuclear import of expression plasmids. As in other fields, chitosan is a promising drug delivery vector with great potential for the fish farming industry. This review highlights state-of-the-art assays using chitosan-based methodologies for delivering nucleic acids into cells, and focuses attention on recent advances in chitosan-mediated gene delivery for fish biotechnology applications. The e ciency of chitosan for gene therapy studies in fish biotechnology is discussed in fields such as fish vaccination against bacterial and viral infection, control of gonadal development and gene overexpression and silencing for overcoming metabolic limitations, such as dependence on protein-rich diets and the low glucose tolerance of farmed fish. Finally, challenges and perspectives on the future developments of chitosan-based gene delivery in fish are also discussed.
Matèries
Matèries (anglès)
Citació
Citació
WU, Yuanbing, RASHIDPOUR, Ania, ALMAJANO PABLOS, Ma. pilar (maría pilar), METÓN TEIJEIRO, Isidoro. Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology. _Polymers_. 2020. Vol. 12, núm. 5, pàgs. E1177. [consulta: 10 de gener de 2026]. ISSN: 2073-4360. [Disponible a: https://hdl.handle.net/2445/164430]