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Data de publicació

2016-08-21

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/103862

Targeting the Microenvironment in Advanced Colorectal Cancer

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Recurs relacionat

http://dx.doi.org/10.1016/j.trecan.2016.08.001

Resum

Colorectal cancer (CRC) diagnosis often occurs at late stages when tumor cells have already disseminated. Current therapies are poorly effective for metastatic disease, the main cause of death in CRC. Despite mounting evidence implicating the tumor microenvironment in CRC progression and metastasis, clinical practice remains predominantly focused on targeting the epithelial compartment. Because CRCs remain largely refractory to current therapies, we must devise alternative strategies. Transforming growth factor (TGF)-β has emerged as a key architect of the microenvironment in poor-prognosis cancers. Disseminated tumor cells show a strong dependency on a TGF-β-activated stroma during the establishment and subsequent expansion of metastasis. We review and discuss the development of integrated approaches focused on targeting the ecosystem of poor-prognosis CRCs.

Matèries

Càncer colorectal, Metàstasi

Matèries (anglès)

Colorectal cancer, Metastasis

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

TAURIELLO, Daniele V. F. and BATLLE, Eduard. Targeting the Microenvironment in Advanced Colorectal Cancer. Trends Cancer. 2016. Vol. 2, num. 9. ISSN 2405-8033. [consulted: 25 of June of 2026]. Available at: https://hdl.handle.net/2445/103862

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