Palmitic and oleic acid: The Yin and Yang of fatty acids in type 2 diabetes mellitus

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dc.contributor.authorPalomer Tarridas, Francesc Xavier
dc.contributor.authorPizarro Delgado, Javier
dc.contributor.authorBarroso Fernández, Emma
dc.contributor.authorVázquez Carrera, Manuel
dc.date.accessioned2020-05-14T08:55:38Z
dc.date.available2020-05-14T08:55:38Z
dc.date.issued2018-03-01
dc.date.updated2020-05-14T08:55:38Z
dc.description.abstractIncreased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve β cell survival. Understanding the molecular mechanisms of the antidiabetic effects of oleic acid may contribute to understanding the benefits of this FA in the prevention or delay of T2DM.
dc.format.extent13 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec676383
dc.identifier.issn1043-2760
dc.identifier.urihttps://hdl.handle.net/2445/160218
dc.language.isoeng
dc.publisherElsevier Current Trends
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.tem.2017.11.009
dc.relation.ispartofTrends in Endocrinology and Metabolism, 2018, vol. 29, num. 3, p. 178-190
dc.relation.urihttps://doi.org/10.1016/j.tem.2017.11.009
dc.rightscc-by-nc-nd (c) Elsevier Current Trends, 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationÀcid oleic
dc.subject.classificationResistència a la insulina
dc.subject.classificationInflamació
dc.subject.classificationDiabetis no-insulinodependent
dc.subject.classificationObesitat
dc.subject.otherOleic acid
dc.subject.otherInsulin resistance
dc.subject.otherInflammation
dc.subject.otherNon-insulin-dependent diabetes
dc.subject.otherObesity
dc.titlePalmitic and oleic acid: The Yin and Yang of fatty acids in type 2 diabetes mellitus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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