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2008

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cc-by, (c) Blanco et al., 2008
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/7445

Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila

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Recurs relacionat

http://dx.doi.org/10.1186/gb-2008-9-9-r134

Resum

Background: The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible for the maintenance of stable transcriptional patterns of many developmental regulators. They bind to specific regions of DNA and direct the post-translational modifications of histones, playing a role in the dynamics of chromatin structure. Results: We have performed genome-wide expression studies of trx and ash2 mutants in Drosophila melanogaster. Using computational analysis of our microarray data, we have identified 25 clusters of genes potentially regulated by TRX. Most of these clusters consist of genes that encode structural proteins involved in cuticle formation. This organization appears to be a distinctive feature of the regulatory networks of TRX and other chromatin regulators, since we have observed the same arrangement in clusters after experiments performed with ASH2, as well as in experiments performed by others with NURF, dMyc, and ASH1. We have also found many of these clusters to be significantly conserved in D. simulans, D. yakuba, D. pseudoobscura and partially in Anopheles gambiae. Conclusion: The analysis of genes governed by chromatin regulators has led to the identification of clusters of functionally related genes conserved in other insect species, suggesting this chromosomal organization is biologically important. Moreover, our results indicate that TRX and other chromatin regulators may act globally on chromatin domains that contain transcriptionally co-regulated genes.

Matèries

Genètica del desenvolupament, Drosòfila melanogaster, Mutació (Biologia)

Matèries (anglès)

Genome studies, Evolution, Development, Model organisms

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

BLANCO, Enrique, PIGNATELLI, Miguel, BELTRAN I AGULLÓ, Sergi, PUNSET, Adrià, PÉREZ-LLUCH, Sílvia, SERRAS RIGALT, Florenci, GUIGÓ SERRA, Roderic, COROMINAS, Montserrat (corominas guiu). Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. _Genome Biology_. 2008. Vol. 9, núm. 134. [consulta: 21 de gener de 2026]. ISSN: 1465-6914. [Disponible a: https://hdl.handle.net/2445/7445]

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