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2011

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/24558

Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC

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http://dx.doi.org/10.1016/j.jchromb.2011.07.018

Abstract

The aim of this study was to develop and validate an analytical method to simultaneously determine European Union-regulated beta-lactams (penicillins and cephalosporins) and quinolones in cow milk. The procedure involves a new solid phase extraction (SPE) to clean-up and pre-concentrate the three series of antibiotics before analysis by liquid chromatography¿tandem mass spectrometry (LC-MS/MS) and ultra-high-performance liquid chromatography¿tandem mass spectrometry (UPLC-MS/MS). LC-MS/MS and UPLC-MS/MS techniques were also compared. The method was validated according to the Directive 2002/657/EC and subsequently applied to 56 samples of raw cow milk supplied by the Laboratori Interprofessional Lleter de Catalunya (ALLIC) (Laboratori Interprofessional Lleter de Catalunya, Control Laboratory Interprofessional of Milk of Catalunya).

Subject

Llet, Quinolones, Química analítica

Subject (English)

Milk, Quinolone antibacterial agents, Analytical chemistry

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citation

JUNZA MARTÍNEZ, Alexandra, et al. Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC. ISSN 1570-0232. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/24558

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