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2003-03-24

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cc-by-nc-sa (c) Zurita, A. J. et al., 2003
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/120651

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours

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Recurs relacionat

https://doi.org/10.1038/sj.bjc.6600803

Resum

This study was undertaken to investigate the expression and predictive value for outcome of multidrug resistance-associated (MDR) proteins P-glycoprotein (Pgp), MRP1, BCRP, and LRP, in advanced testicular germ-cell tumours (TGCT). Paraffin-embedded sections from 56 previously untreated patients with metastatic TGCT were immunostained for Pgp, MRP1, BCRP, and LRP. All patients received platinum-based chemotherapy after orchidectomy. Immunostaining was related to clinicopathological parameters, response to chemotherapy, and outcome. Strong and intermediate expressions of the different MDR-related proteins were: 27 and 41% (Pgp), 54 and 37% (MRP1), 86 and 7% (BCRP), and 14 and 29% (LRP). P-glycoprotein and MRP1 associated, respectively, to low AFP (P=0.026) and high LDH levels (P=0.014), whereas LRP expression associated with high β-hCG levels (P=0.003) and stage IV tumours (P=0.029). No correlation was found between Pgp, MRP1, and BCRP expression and response to chemotherapy and survival. In contrast, patients with LRP-positive tumours (strong or intermediate expression) had shorter progression-free (P=0.0006) and overall survival (P=0.0116) than LRP-negative patients, even after individual log-rank adjustments by statistically associated variables. Our data suggest that a positive LRP immunostaining at the time of diagnosis in metastatic TGCT is associated with an adverse clinical outcome.

Matèries

Malalties del testicle, Cèl·lules germinals, Tumors, Expressió gènica, Proteïnes supressores de tumors, Resistència als medicaments

Matèries (anglès)

Testis diseases, Germ cells, Tumors, Gene expression, Tumor suppressor protein, Drug resistance

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Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Ciències Clíniques)

Citació

ZURITA, A. j., DIESTRA, J. e., CONDOM I MUNDÓ, Enric, GARCÍA DEL MURO SOLANS, Xavier, SCHEFFER, G. l., SCHEPER, R. j., PÉREZ, J., GERMÀ LLUCH, José ramón, IZQUIERDO, M. a.. Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours. _British Journal of Cancer_. 2003. Vol. 88, núm. 6, pàgs. 879-886. [consulta: 23 de gener de 2026]. ISSN: 0007-0920. [Disponible a: https://hdl.handle.net/2445/120651]

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