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Article

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Published version

Publication date

2022-10-01

Publication license

cc-by.nc (c) Lu, 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215878

Endolysosomal cholesterol export: More than just NPC1

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https://doi.org/10.1002/bies.202200111

Abstract

NPC1 plays a central role in cholesterol egress from endolysosomes, a critical step for maintaining intracellular cholesterol homeostasis. Despite recent advances in the field, the full repertoire of molecules and pathways involved in this process remains unknown. Emerging evidence suggests the existence of NPC1-independent, alternative routes. These may involve vesicular and non-vesicular mechanisms, as well as release of extracellular vesicles. Understanding the underlying molecular mechanisms that bypass NPC1 function could have important implications for the development of therapies for lysosomal storage disorders. Here we discuss how cholesterol may be exported from lysosomes in which NPC1 function is impaired.

Subject

Colesterol, Glicoproteïnes

Subject (English)

Cholesterol, Glycoproteins

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Articles publicats en revistes (Biomedicina)

Citation

LU, Albert. Endolysosomal cholesterol export: More than just NPC1. BioEssays. 2022. Vol. 44, num. 10, pags. 1-12. ISSN 0265-9247. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/215878

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