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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/173157
Psychosocial stress and epigenetic aging
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Abstract
Aging is the single most important risk factor for diseases that are currently the leading causes of morbidity and mortality. However, there is considerable inter-individual variability in risk for aging-related disease, and studies suggest that biological age can be influenced by multiple factors, including exposure to psychosocial stress. Among markers of biological age that can be affected by stress, the present article focuses on the so-called measures of epigenetic aging: DNA methylation-based age predictors that are measured in a range of tissues, including the brain, and can predict lifespan and healthspan. We review evidence linking exposure to diverse types of psychosocial stress, including early-life stress, cumulative stressful experiences, and low socioeconomic status, with accelerated epigenetic aging as a putative mediator of the effects of psychosocial environment on health and disease. The chapter also discusses methodological
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PALMA-GUDIEL, Helena, et al. Psychosocial stress and epigenetic aging. International Review of Neurobiology. 2019. Vol. 150, num. 107-128. ISSN 0074-7742. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/173157