Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/148000
Understanding the Connetion between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Cytosine methylation is one of the most important epigenetic marks that regulate the process of gene expression. Here, we have examined the effect of epigenetic DNA methylation on nucleosomal stability using molecular dynamics simulations and elastic deformation models. We found that methylation of CpG steps destabilizes nucleosomes, especially when these are placed in sites where the DNA minor groove faces the histone core. The larger stiffness of methylated CpG steps is a crucial factor behind the decrease in nucleosome stability. Methylation changes the positioning and phasing of the nucleosomal DNA, altering the accessibility of DNA to regulatory proteins, and accordingly gene functionality. Our theoretical calculations highlight a simple physical-based explanation on the foundations of epigenetic signaling.
Matèries
Matèries (anglès)
Citació
Citació
PORTELLA, Guillem, BATTISTINI, Federica and OROZCO LÓPEZ, Modesto. Understanding the Connetion between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations. PLoS Computational Biology. 2013. Vol. 9, num. 11, pags. e1003354. ISSN 1553-734X. [consulted: 2 of July of 2026]. Available at: https://hdl.handle.net/2445/148000