Miniatura

Fitxers

576239.pdf (218.15 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2008-11

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/61729

Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

Resum

Background: The enzyme fatty acid synthase (FASN) is highly expressed in many human carcinomas and its inhibition is cytotoxic to human cancer cells. The use of FASN inhibitors has been limited until now by anorexia and weight loss, which is associated with the stimulation of fatty acid oxidation. Materials and Methods: The in vitro effect of (-)-epigallocatechin-3-gallate (EGCG) on fatty acid metabolism enzymes, on apoptosis and on cell signalling was evaluated. In vivo, the effect of EGCG on animal body weight was addressed. Results: EGCG inhibited FASN activity, induced apoptosis and caused a marked decrease of human epidermal growth factor receptor 2 (HER2), phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular (signal)-regulated kinase (ERK) 1/2 proteins, in breast cancer cells. EGCG did not induce a stimulatory effect on CPT-1 activity in vitro (84% of control), or on animal body weight in vivo (99% of control). Conclusion: EGCG is a FASN inhibitor with anticancer activity which does not exhibit cross-activation of fatty acid oxidation and does not induce weight loss, suggesting its potential use as an anticancer drug.

Matèries

Àcids grassos, Metabolisme, Enzimologia, Quimioteràpia del càncer, Medicaments antineoplàstics, Efectes secundaris dels medicaments, Te, Càncer de mama, Aprimament

Matèries (anglès)

Fatty acids, Metabolism, Enzymology, Cancer chemotherapy, Antineoplastic agents, Drug side effects, Tea, Breast cancer, Weight loss

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

PUIG I MIQUEL, Teresa, RELAT PARDO, Joana, MARRERO GONZÁLEZ, Pedro f., HARO BAUTISTA, Diego, BRUNET, Joan, COLOMER BOSCH, Ramón. Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals. _Anticancer Research_. 2008. Vol. 28, núm. 6A, pàgs. 3671-3676. [consulta: 20 de gener de 2026]. ISSN: 0250-7005. [Disponible a: https://hdl.handle.net/2445/61729]

Exportar metadades

JSON - METS

Compartir registre