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Treball de fi de grau

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cc-by-nc-nd (c) Batlle, 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122796

Benzodiazepines and derivatives. Overview, analysis and synthesis

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[eng] Benzodiazepines are widely used drugs for several indications. This study provides, on the one hand, a global vision of this family starting for their fortuitous discovery, the synthesis of their derivatives, their mechanism of action which is well known nowadays, the actual classification according to the chemical structure and the pharmacokinetic properties and their uses and indications, including the traditional and the new ones. On the other hand, the study is focused in the dependence and tolerance derived from their use, many times lead by a misuse of the patient, wrong prescriptions or extended treatments. A withdrawal program is proposed, including the important factors or criteria to success, with a slow and gradual reduction of these drugs to avoid relapse or severe adverse effects. New lines of research related to benzodiazepines are taken into account, including the new therapeutic uses but also the adverse effects in short and long-term. They are also analyzed the new discoveries concerning the non-benzodiazepinic drugs due to the close relation they have with benzodiazepines.

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Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2018. Tutora: Maria Dolors Pujol Dilme

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BATLLE ROCAFORT, Elisabet. Benzodiazepines and derivatives. Overview, analysis and synthesis. [consulta: 15 de desembre de 2025]. [Disponible a: https://hdl.handle.net/2445/122796]

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