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Article

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Published version

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2011

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cc-by (c) García Garcerà, M. et al., 2011
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/43561

Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics

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http://dx.doi.org/10.1371/journal.pone.0024161

Abstract

Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks.

Subject

ADN fòssil, ADN, Paleobiologia

Subject (English)

Fossil DNA, DNA, Paleobiology

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

GARCÍA GARCERÀ, M., et al. Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics. PLoS One. 2011. Vol. 6, num. 8, pags. e24161. ISSN 1932-6203. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/43561

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