Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/193242
Phospholipid Membrane Transport and Associated Diseases
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized phospholipids. These damaged phospholipids have been related to prevalent diseases such as atherosclerosis or non-alcoholic steatohepatitis (NASH) because they alter gene expression and induce cellular stress and apoptosis. One of the main sites of phospholipid synthesis is the endoplasmic reticulum (ER). ER association with other organelles through membrane contact sites (MCS) provides a close apposition for lipid transport. Additionally, an important advance in this small cytosolic gap are lipid transfer proteins (LTPs), which accelerate and modulate the distribution of phospholipids in other organelles. In this regard, LTPs can be established as an essential point within phospholipid circulation, as relevant data show impaired phospholipid transport when LTPs are defected. This review will focus on phospholipid function, metabolism, non-vesicular transport, and associated diseases.
Subject
Subject (English)
Citation
Citation
VENTURA, Raúl, MARTÍNEZ-RUIZ, Inma and HERNÁNDEZ ALVAREZ, María Isabel. Phospholipid Membrane Transport and Associated Diseases. Biomedicines. 2022. Vol. 10, num. 5. ISSN 2227-9059. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/193242