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2011

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/21368

Generation of biological association networks: A novel strategy to detect new targets in cancer therapy

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http://hdl.handle.net/2445/32392

Resum

The aim of this work was to design a novel strategy to detect new targets for anticancer treatments. The rationale was to build Biological Association Networks from differentially expressed genes in drug-resistant cells to identify important nodes within the Networks. These nodes may represent putative targets to attack in cancer therapy, as a way to destabilize the gene network developed by the resistant cells to escape from the drug pressure. As a model we used cells resistant to methotrexate (MTX), an inhibitor of DHFR. Selected node-genes were analyzed at the transcriptional level and from a genotypic point of view. In colon cancer cells, DHFR, the AKR1 family, PKC¿, S100A4, DKK1, and CAV1 were overexpressed while E-cadherin was lost. In breast cancer cells, the UGT1A family was overexpressed, whereas EEF1A1 was overexpressed in pancreatic cells. Interference RNAs directed against these targets sensitized cells towards MTX.

Descripció

Podeu consultar el llibre complet a: http://www.trnres.com/ebookcontents.php?id=149

Matèries

Càncer, Quimioteràpia, Farmacogenètica

Matèries (anglès)

Cancer, Chemotherapy, Pharmacogenetics

Citació

Col·leccions

Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular)

Citació

SELGA I COMA, Elisabet, ALMAGRO GARCÍA, Ma. cristina de, OLEAGA SANCHO, Carlota, MENCÍA TRINCHANT, Núria, RAMÍREZ, Sara, RUIZ, F. xavier, FARRÉS I VICÉN, Jaume, PARÉS I CASASAMPERA, Xavier, THIBAUT, Rémi, PORTE VISA, Cinta, NOÉ MATA, Verónica, CIUDAD I GÓMEZ, Carlos julián. Generation of biological association networks: A novel strategy to detect new targets in cancer therapy. _Recent Advances in Pharmaceutical Sciences_. 2011. Vol.  Chapter 1, núm. 1-33. [consulta: 22 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/21368]

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