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7. Garcia-Basteiro A_IJTLD_2025.pdf (397.17 KB)

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2025-02-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/228194

BMI as a predictor of progression from TB infection to active TB in PLHIV

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https://doi.org/10.5588/ijtld.24.0287

Resum

BACKGROUND: Low body mass index (BMI) is a globally important risk factor for TB progression. Little is known about this association in people living with HIV (PLHIV) and the functional form of the BMI-TB incidence curve. METHODS: Secondary analysis of a randomised controlled trial of TB preventive therapy among PLHIV in South Africa, Mozambique, and Ethiopia. Participants received 3 months of weekly high-dose rifapentine-isoniazid given once or twice over a period of 2 years. Multivariable fractional polynomials (MFPs) were used to investigate functional forms of BMI. Time to incident TB was modelled using Cox's proportional hazard regression. RESULTS: A total of 76 TB events were documented, giving an overall TB incidence rate of 1.2 per 100 person-years (95%CI 1.0-1.6). Baseline BMI = 30 kg/m(2) was associated with a lower hazard of TB (aHR 0.5, 95% CI 0.2-1.0). Continuous and categorical BMI showed weak evidence of quadratic dose-response relationships (P = 0.08 and P = 0.09, respectively). MFP analysis was consistent with a decline in TB incidence for increasing BMI to around 25 kg/m(2), followed by a less steep decline in TB incidence for increasing BMI >25 kg/m(2). CONCLUSIONS: In PLHIV, BMI showed an inverse log-linear association with TB incidence. The MFP approach showed that the relationship is more complex than a simple log-linear association.

Matèries

Tuberculosi, Dagaaba (Poble africà), Vacuna de la malària

Matèries (anglès)

Tuberculosis, Dagaaba (African people), Malaria vaccine

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Articles publicats en revistes (ISGlobal)

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NGUENHA, Dinis, NDEBELE, Felex, SAAVEDRA, Belén, MAMBUQUE, Edson, ACÁCIO, Sozinho, CARDENAS, Vicky, CHIHOTA, Violet, GRANT, Alison, YIMER, Getnet, FIELDING, Katherine, COBELENS, Frank, CHURCHYARD, Gavin, GARCÍA-BASTEIRO, Alberto l.. BMI as a predictor of progression from TB infection to active TB in PLHIV. _International Journal of Tuberculosis and Lung Disease_. 2025. Vol. 29, núm. 2, pàgs. 54-59. [consulta: 5 de maig de 2026]. ISSN: 1815-7920. [Disponible a: https://hdl.handle.net/2445/228194]

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