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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/158458
DNA-origami-aided lithography for sub-10 nanometer pattern printing
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We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces.
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GÁLLEGO, Isaac, et al. DNA-origami-aided lithography for sub-10 nanometer pattern printing. MDPI Proceedings. 2017. Vol. 1, num. 4, pags. 325. ISSN 2504-3900. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/158458