Miniatura

Fitxers

706774.pdf (999.22 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2020-12-03

Llicència de publicació

cc-by (c) Paules, Cristina et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176997

Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41598-020-78207-3

Resum

Fetal growth restriction defined as the failure to achieve the fetal genetic growth potential is a major cause of perinatal morbidity and mortality. The role of maternal adaptations to placental insufficiency in this disorder is still not fully understood. We aimed to investigate the biological processes and protein-protein interactions involved in late-onset fetal growth restriction in particular. We applied 2D nano LC-MS/MS proteomics analysis on maternal blood samples collected at the time of delivery from 5 singleton pregnancies with late-onset fetal growth restriction and 5 uncomplicated pregnancies. Data were analyzed using R package 'limma' and Ingenuity Pathway Analysis. 25 proteins showed significant changes in their relative abundance in late-onset fetal growth restriction (p value < 0.05). Direct protein-protein interactions network demonstrated that Neurogenic locus notch homolog protein 1 (NOTCH1) was the most significant putative upstream regulator of the observed profile. Gene ontology analysis of these proteins revealed the involvement of 14 canonical pathways. The most significant biological processes were efflux of cholesterol, efflux of phospholipids, adhesion of blood cells, fatty acid metabolism and dyslipidemia. Future studies are warranted to validate the potential role of the detected altered proteins as potential therapeutic targets in the late-onset form of fetal growth restriction.

Matèries

Creixement fetal, Mort del fetus

Matèries (anglès)

Fetal growth, Fetal death

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Centres Científics i Tecnològics de la Universitat de Barcelona (CCiTUB))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PAULES, Cristina, YOUSSEF, Lina, MIRANDA, Jezid, CROVETTO, Francesca, ESTANYOL I ULLATE, Josep maria, FERNÀNDEZ, Guerau, CRISPI BRILLAS, Fàtima, GRATACÓS SOLSONA, Eduard. Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. _Scientific Reports_. 2020. Vol. 10, núm. 1, pàgs. 21033. [consulta: 23 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/176997]

Exportar metadades

JSON - METS

Compartir registre