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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172610
Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved.
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Diabetes mellitus is a metabolic disorder characterized by dysfunction, loss, or insufficient mass of β cells. The main function of β cells is to produce and secrete insulin, the hormone responsible for the regulation of blood glucose levels. Type 1 diabetes (T1D) results from autoimmune destruction of β cells, while type 2 diabetes (T2D) mostly results from β-cell dysfunction or peripheral tissue resistance to insulin, often culminating in β-cell death. Thus, both forms of diabetes can benefit from restoration of β-cell mass. Currently, islet transplantation is the only way to provide new β cells to diabetic patients, but the scarcity of compatible cadaveric donors makes this approach available to only few patients; moreover, it requires lifelong immune suppression.
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AFELIK, Solomon, ROVIRA, Meritxell. Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved.. _Genome Medicine_. 2017. Vol. 9, núm. 42. [consulta: 21 de gener de 2026]. ISSN: 1756-994X. [Disponible a: https://hdl.handle.net/2445/172610]