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1-H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia

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The authors performed neuropsychological and 1H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and reduced NAA/choline values in the MTR. Neuropsychological testing showed group differences in tasks related to attention and memory. These results indicate persistent dysfunctions in cerebral structures vulnerable to hypoxia and demonstrate the utility of MRS for the long-term evaluation of cerebral sequelae of neonatal asphyxia.

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MAÑERU ZUNAZARREN, Cristina, et al. 1-H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia. Neurology. 2001. Vol. 57, num. 6, pags. 1115-1118. ISSN 0028-3878. [consulted: 28 of June of 2026]. Available at: https://hdl.handle.net/2445/223643

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