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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183513
The background K+ channel TRESK in sensory physiology and pain
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Abstract
TRESK belongs to the K2P family of potassium channels, also known as background or leak potassium channels due to their biophysical properties and their role regulating membrane potential of cells. Several studies to date have highlighted the role of TRESK in regulating the excitability of specific subtypes of sensory neurons. These findings suggest TRESK could be involved in pain sensitivity. Here, we review the different evidence available that involves the channel in pain and sensory perception, from studies knocking out the channel or overexpressing it to identified mutations that link the channel to migraine pain. In addition, the therapeutic possibilities are discussed, as targeting the channel seems an interesting therapeutic approach to reduce nociceptor activation and to decrease pain.
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ANDRES, Alba, et al. The background K+ channel TRESK in sensory physiology and pain. International Journal of Molecular Sciences. 2020. Vol. 21, num. 15, pags. 5206-5220. ISSN 1661-6596. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/183513