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668059.pdf (3.43 MB)

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Article

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Data de publicació

2016

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cc-by (c) Paoli, Roberto et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/113453

Mimicking the kidney: A key role in organ-on-chip development

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Recurs relacionat

https://doi.org/10.3390/mi7070126

Resum

Pharmaceutical drug screening and research into diseases call for significant improvement in the effectiveness of current in vitro models. Better models would reduce the likelihood of costly failures at later drug development stages, while limiting or possibly even avoiding the use of animal models. In this regard, promising advances have recently been made by the so-called "organ-on-chip"(OOC) technology. By combining cell culture with microfluidics, biomedical researchers have started to develop microengineered models of the functional units of human organs. With the capacity to mimic physiological microenvironments and vascular perfusion, OOC devices allow the reproduction of tissue- and organ-level functions. When considering drug testing, nephrotoxicity is a major cause of attrition during pre-clinical, clinical, and post-approval stages. Renal toxicity accounts for 19% of total dropouts during phase III drug evaluation more than half the drugs abandoned because of safety concerns. Mimicking the functional unit of the kidney, namely the nephron, is therefore a crucial objective. Here we provide an extensive review of the studies focused on the development of a nephron-on-chip device.

Matèries

Sistema monoxip, Malalties del ronyó, Nefrologia

Matèries (anglès)

Systems on a chip, Kidney diseases, Nephrology

Citació

Col·leccions

Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

PAOLI, Roberto and SAMITIER I MARTÍ, Josep. Mimicking the kidney: A key role in organ-on-chip development. Micromachines. 2016. Vol. 7, num. 7, pags. 126. ISSN 2072-666X. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/113453

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