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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/114205
Which early life events or current environmental and lifestyle factors influence lung function in adolescents? - results from the GINIplus & LISAplus studies
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BACKGROUND: Various factors may affect lung function at
different stages in life. Since investigations that
simultaneously consider several factors are rare, we examined
the relative importance of early life, current
environmental/lifestyle factors and allergic diseases on lung
function in 15-year-olds. METHODS: Best subset selection was
performed for linear regression models to investigate
associations between 21 diverse early life events and current
factors with spirometric parameters (forced vital capacity,
forced expiratory volume in 1 s and maximal mid-expiratory flow
(FEF25-75)) in 1326 participants of the German GINIplus and
LISAplus birth cohorts. To reduce model complexity, one model
for each spirometric parameter was replicated 1000 times in
random subpopulations (N = 884). Only those factors that were
included in >70% of the replication models were retained in
the final analysis. RESULTS: A higher peak weight velocity and
early lung infections were the early life events prevalently
associated with airflow limitation and FEF25-75. Current
environmental/lifestyle factors at age 15 years and allergic
diseases that were associated with lung function were: indoor
second-hand smoke exposure, vitamin D concentration, body mass
index (BMI) and asthma status. Sex and height captured the
majority of the explained variance (>75%), followed by BMI
(
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LUZAK, Agnes, FUERTES, Elaine, FLEXEDER, Claudia, STANDL, Marie, VON BERG, Andrea, BERDEL, Dietrich, KOLETZKO, Sibylle, HEINRICH, Joachim, NOWAK, Dennis, SCHULZ, Holger. Which early life events or current environmental and lifestyle
factors influence lung function in adolescents? - results from
the GINIplus & LISAplus studies. _Respiratory Research_. 2017. Vol. 18, núm. 1, pàgs. 138. [consulta: 1 de febrer de 2026]. ISSN: 1465-9921. [Disponible a: https://hdl.handle.net/2445/114205]