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Clotting activity of polyphosphate-functionalized silica nanoparticles
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We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.
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KUDELA, Damien, et al. Clotting activity of polyphosphate-functionalized silica nanoparticles. Angewandte Chemie. 2015. Vol. 127, num. 3. ISSN 0044-8249. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/62752