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Article

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Accepted version

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2013-02

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218314

Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrrhopic factors in cocaine dependence

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https://doi.org/10.1111/gbb.12013

Abstract

Cocaine dependence is a neuropsychiatric disorder in which both environmental and genetic factors are involved. Several processes, that include reward and neuroadaptations, mediate the transition from use to dependence. In this regard, dopamine and serotonin neurotransmission systems are clearly involved in reward and other cocaine-related effects, whereas neurotrophic factors may be responsible for neuroadaptations associated with cocaine dependence. We examined the contribution to cocaine dependence of 37 genes related to the dopaminergic and serotoninergic systems, neurotrophic factors and their receptors through a case-control association study with 319 Single Nucleotide Polymorphisms (SNPs) selected according to genetic coverage criteria in 432 cocaine-dependent patients and 482 sex-matched unrelated controls. Single marker analyses provided evidence for association of the serotonin receptor HTR2A with cocaine dependence (rs6561333; nominal P-value adjusted for age = 1.9e-04, OR = 1.72 (1.29-2.30)). When patients were subdivided according to the presence or absence of psychotic symptoms, we confirmed the association between cocaine dependence and HTR2A in both subgroups of patients. Our data show additional evidence for the involvement of the serotoninergic system in the genetic susceptibility to cocaine dependence.

Subject

Genètica, Drogoaddicció, Dopamina, Serotonina

Subject (English)

Genetics, Drug addiction, Dopamine, Serotonin

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

FERNÀNDEZ CASTILLO, Noèlia, et al. Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrrhopic factors in cocaine dependence. Genes. Brain and Behavior. Vol.  2012, num. 12, pags. 1. ISSN 1601-1848. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/218314

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