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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/201194
Microwave-Based Colonoscopy: Preclinical Evaluation in an Ex Vivo Human Colon Model
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Introduction: Microwave imaging can obtain 360° anatomical and functional images of the colon representing the existing contrast in dielectric properties between different tissues. Microwaves are safe (nonionizing) and have the potential of reducing the visualization problems of conventional colonoscopy. This study assessed the efficacy of a microwave-based colonoscopy device to detect neoplastic lesions in an ex vivo human colon model. Methods: Fresh surgically excised colorectal specimens containing cancer or polyps were fixed to a 3D positioning system, and the accessory device was introduced horizontally inside the ex vivo colon lumen and moved along it simulating a real colonoscopy exploration. Measurements of the colon were taken every 4 mm with the microwave-based colonoscopy device and processed with a microwave imaging algorithm. Results: 14 ex vivo human colorectal specimens with carcinomas (n = 11) or adenomas with high grade dysplasia (n = 3) were examined with a microwave-based device. Using a detection threshold of 2.79 for the dielectric property contrast, all lesions were detected without false positives or false negatives. Conclusions: This study demonstrates the use of a microwave-based device to be used as an accessory of a standard colonoscope to detect neoplastic lesions in surgically excised colorectal specimens.
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FERNÁNDEZ ESPARRACH, Glòria, et al. Microwave-Based Colonoscopy: Preclinical Evaluation in an Ex Vivo Human Colon Model. Gastroenterology Research and Practice. 2022. Vol. 2022, num. 9522737. ISSN 1687-6121. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/201194