Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127191
Urinary cell microRNA-based prognostic classifier for nonmuscle invasive bladder cancer
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Current prognostic tools for non-muscle invasive bladder cancer (NMIBC) do not have enough discriminative capacity to predict the risk of tumour progression. This study aimed to identify urinary cell microRNAs that may be useful as non-invasive predictive biomarkers of tumour progression in NMIBC patients. To this end, 210 urine samples from NMIBC patients were included in the study. RNA was extracted from urinary cells and expression of 8 microRNAs, previously described by our group, was analysed by quantitative PCR. A tumour progression predicting model was developed by Cox regression analysis and validated by bootstrapping. Regression analysis identified miR-140-5p and miR-92a-3p as independent predictors of tumour progression. The risk score derived from the model containing these two microRNAs was able to discriminate between two groups with a highly significant different probability of tumour progression (HR, 5.204; p<0.001) which was maintained when patients were stratified according to tumour risk. The algorithm was also able to identify two groups with different cancer-specific survival (HR, 3.879; p=0.021). Although the data needs to be externally validated, miRNA analysis in urine appears to be a valuable prognostic tool in NMIBC patients.
Subject
Subject (English)
Citation
Citation
INGELMO-TORRES, Mercedes, et al. Urinary cell microRNA-based prognostic classifier for nonmuscle invasive bladder cancer. Oncotarget. 2017. Vol. 8, num. 11, pags. 18238-18247. ISSN 1949-2553. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/127191