Miniatura

Fitxers

641814.pdf (3.3 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2014-03-31

Llicència de publicació

cc-by (c) Alaña, Lide et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/96212

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1186/1476-4598-13-74

Resum

Background PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in prostate cancer (PC) and other neoplasms. Here we report its interaction with the Notch pathway and its involvement in PC progression. Methods Stable PTOV1 knockdown or overexpression were performed by lentiviral transduction. Protein interactions were analyzed by co-immunoprecipitation, pull-down and/or immunofluorescence. Endogenous gene expression was analyzed by real time RT-PCR and/or Western blotting. Exogenous promoter activities were studied by luciferase assays. Gene promoter interactions were analyzed by chromatin immunoprecipitation assays (ChIP). In vivo studies were performed in the Drosophila melanogaster wing, the SCID-Beige mouse model, and human prostate cancer tissues and metastasis. The Excel package was used for statistical analysis [...].

Matèries

Càncer de pròstata, Marcadors tumorals

Matèries (anglès)

Prostate cancer, Tumor markers

Citació

Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Fonaments Clínics)

Citació

ALAÑA, Lide, SESÉ I FAUSTINO, Marta, CÁNOVAS, Verónica, PUNYAL, Yolanda, FERNÁNDEZ, Yolanda, ABASOLO, Ibane, TORRES, Inés de, RUIZ, Cristina, ESPINOSA BLAY, Lluís, BIGAS SALVANS, Anna, RAMÓN Y CAJAL AGÜERAS, Santiago, FERNÁNDEZ RUIZ, Pedro luis, SERRAS RIGALT, Florenci, COROMINAS, Montserrat (corominas guiu), THOMSON, Timothy m., PACIUCCI BARZANTI, Rosanna. Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression. _Molecular Cancer_. 2014. Vol. 13, núm. 74, pàgs. 1-16. [consulta: 26 de febrer de 2026]. ISSN: 1476-4598. [Disponible a: https://hdl.handle.net/2445/96212]

Exportar metadades

JSON - METS

Compartir registre