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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/155058
State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response
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Chagas disease is caused by infection with the parasite
Trypanosoma cruzi, which might lead to a chronic disease state
and drive to irreversible damage to the heart and/or digestive
tract tissues. Endemic in 21 countries in the Americas, it is
the neglected disease with a highest burden in the region.
Current estimates point at ~6 million people infected, of which
~30% will progress onto the symptomatic tissue disruptive stage.
There is no vaccine but there are two anti-parasitic drugs
available: benznidazole and nifurtimox. However, their efficacy
is variable at the chronic symptomatic stage and both have
frequent adverse effects. Since there are no prognosis markers,
drugs should be administered to all T. cruzi-infected
individuals in the indeterminate and early symptomatic stages.
Nowadays, there are no tests-of-cure either, which greatly
undermines patients' follow-up and the search of safer and more
efficacious drugs. Therefore, the identification and validation
of biomarkers of disease progression and/or treatment response
on which to develop tests of prognosis and/or cure is a major
research priority. Both parasite- and host-derived markers have
been investigated. In the present manuscript we present an
updated outlook of the latter.
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CORTÉS SERRA, Núria, LOSADA, Irene, PINAZO, Maria-jesus, FERNÁNDEZ BECERRA, María del carmen, GASCÓN I BRUSTENGA, Joaquim, ALONSO PADILLA, Julio. State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response. _Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease_. 2020. Vol. 1886, núm. 7. [consulta: 23 de gener de 2026]. ISSN: 0925-4439. [Disponible a: https://hdl.handle.net/2445/155058]