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2018-11-22

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cc-by (c) Ramos Vicente, David et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/157419

Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

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https://doi.org/10.7554/eLife.35774

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Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.

Matèries

Receptors de neurotransmissors

Matèries (anglès)

Neurotransmitter receptors

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

RAMOS VICENTE, David, JI, Jie, GRATACÒS I BATLLE, Esther, GOU, Gemma, REIG VIADER, Rita, LUÍS, Javier, BURGUERA, Demian, NAVAS PÉREZ, Enrique, GARCÍA FERNÁNDEZ, Jordi, FUENTES PRIOR, Pablo, ESCRIVA, Hector, ROHER ARMENTIA, Nerea, SOTO DEL CERRO, David, BAYÉS, Àlex. Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events. _eLife_. 2018. Vol. 7, núm. e35774, pàgs. e35774. [consulta: 23 de gener de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/157419]

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