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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184118
Drug-free Enzyme-based bactericidal nanomotors against pathogenic bacteria
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The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzyme- based nanomotors for the treatment of bacterial urinary-tract infections. We develop nanomotors consisting of mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or urease and lysozyme (M- MSNPs), and use them against nonpathogenic planktonic Escherichia coli. U-MSNPs exhibited the highest bactericidal activity due to biocatalysis of urea into NaHCO3 and NH3, which also propels U-MSNPs. In addition, U-MSNPs in concentrations above 200 μg/mL were capable of successfully reducing 60% of the biofilm biomass of a uropathogenic E. coli strain. This study thus provides a proof-of-concept, demonstrating that enzyme-based nanomotors are capable of fighting infectious diseases. This approach could potentially be extended to other kinds of diseases by selecting appropriate biomolecules.
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VILELA, Diana, BLANCO-CABRA, Núria, EGUSKIZA, Ander, HORTELAO, Ana c., TORRENTS SERRA, Eduard, SÁNCHEZ, Samuel. Drug-free Enzyme-based bactericidal nanomotors against pathogenic bacteria. _ACS Applied Materials & Interfaces_. 2021. Vol. 13, núm. 13, pàgs. 14964-14973. [consulta: 24 de gener de 2026]. ISSN: 1944-8244. [Disponible a: https://hdl.handle.net/2445/184118]