Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

723334.pdf (34.55 MB)

Document type

Article

Version

Published version

Publication date

2022-04-12

Publication license

cc-by (c) Rech, Gabriel E. et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/185555

Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1038/s41467-022-29518-8

Abstract

High quality reference genomes are crucial to understanding genome function, structure and evolution. The availability of reference genomes has allowed us to start inferring the role of genetic variation in biology, disease, and biodiversity conservation. However, analyses across organisms demonstrate that a single reference genome is not enough to capture the global genetic diversity present in populations. In this work, we generate 32 high-quality reference genomes for the well-known model species D. melanogaster and focus on the identification and analysis of transposable element variation as they are the most common type of structural variant. We show that integrating the genetic variation across natural populations from five climatic regions increases the number of detected insertions by 58%. Moreover, 26% to 57% of the insertions identified using long-reads were missed by short-reads methods. We also identify hundreds of transposable elements associated with gene expression variation and new TE variants likely to contribute to adaptive evolution in this species. Our results highlight the importance of incorporating the genetic variation present in natural populations to genomic studies, which is essential if we are to understand how genomes function and evolve.

Subject

Drosòfila, Expressió gènica

Subject (English)

Drosophila, Gene expression

Citation

Collections

Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Publicacions de projectes de recerca finançats per la UE

Citation

RECH, Gabriel E., et al. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Nature Communications. 2022. Vol. 13, num. 1948, pags. 1-16. ISSN 2041-1723. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/185555

Export metadata

JSON - METS

Share record