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2020-05-25

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cc-by-nc (c) Benejam, Bessy et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/195526

Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests

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https://doi.org/10.1002/dad2.12047

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Introduction: We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population-based cohort of adults with Down syndrome (DS). Methods: Cross-sectional study. DS participants were classified into asymptomatic, prodromal AD and AD dementia, based on neurologist's judgment blinded to neuropsychological data (Cambridge Cognitive Examination for Older Adults with Down's syndrome [CAMCOG-DS] and modified Cued Recall Test [mCRT]). We compared the cutoffs derived from the normative data in young adults with DS to those from receiveroperating characteristic curve (ROC) analysis. Results: Diagnostic performance of the CAMCOG-DS and modified Cued Recall Test (mCRT) in subjects with mild and moderate levels of intellectual disability (ID) was high, both for diagnosing prodromal AD and AD dementia (area under the curve [AUC] 0.73- 0.83 and 0.90-1, respectively). The cutoffs derived from the normative data were similar to those derived from the ROC analyses. Discussion: Diagnosing prodromal AD and AD dementia in DS with mild and moderate ID using population norms for neuropsychological tests is possible with high diagnostic accuracy.

Matèries

Síndrome de Down, Malaltia d'Alzheimer, Demència, Teràpia cognitiva, Tests neuropsicològics, Anàlisi de conducta

Matèries (anglès)

Down syndrome, Alzheimer's disease, Dementia, Cognitive therapy, Neuropsychological tests, Behavioral assessment

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citació

BENEJAM, Bessy, VIDELA, Laura, VILAPLANA, Eduard, BARROETA, Isabel, CARMONA IRAGUI, María, ALTUNA, Miren, VALLDENEU, Silvia, FERNÁNDEZ, Susana, GIMÉNEZ, Sandra, IULITA, Maria florencia, GARZÓN, Diana, BEJANIN, Alexandre, BARTRÉS FAZ, David, VIDELA, Sebastià, ALCOLEA, Daniel, BLESA GONZÁLEZ, Rafael, LLEÓ BISA, Alberto, FORTEA, Juan. Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests. _Alzheimer’s & Dementia: Diagnosis_. Assessment & Disease Monitoring. Vol.  2020, núm. 12, pàgs. 1. [consulta: 22 de gener de 2026]. ISSN: 1552-5260. [Disponible a: https://hdl.handle.net/2445/195526]

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