Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

DRAB_PhD_THESIS.pdf (4.42 MB)

Document type

Doctoral thesis

Version

Published version

Publication date

2021-07-09

Publication license

cc by (c) Ahumada Brena, David Ricardo, 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/200760

Ancestral roles of IĸB proteins in Caenorhabditis elegans

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

Abstract

[eng] Mammalian Inhibitor-of-kappa-B (IκBs) proteins exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness and cell differentiation. However, the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB1 are IκB homologs in aenorhabditis elegans, which lacks NF-κB nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans IκBs in chromatin regulation. Further supporting this possibility (i) we detected NFKI-1 in the nucleus of cells; (ii) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (iii) and associate with chromatin in vivo, and (iv) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral IκB proteins modulate chromatin marks with an impact on development.

Subject

Epigenètica, Càncer, Proteïnes supressores de tumors, Models animals en la investigació

Subject (English)

Epigenetics, Cancer, Tumor suppressor protein, Animal models in research

Citation

Collections

Tesis Doctorals - Facultat - Medicina

Citation

AHUMADA BRENA, David Ricardo. Ancestral roles of IĸB proteins in Caenorhabditis elegans. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/200760

Export metadata

JSON - METS

Share record